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Erener, S.

Diabetes, infection risk and COVID-19.

Mol. Metab. 39:101044 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: Individuals with diabetes are at a greater risk of hospitalization and mortality resulting from viral, bacterial, and fungal infections. The coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread quickly to more than 213 countries and claimed 395,779 lives as of June 7, 2020. Notably, in several studies, diabetes is one of the most reported comorbidities in patients with severe COVID-19.Scope of review: In this review, I summarize the clinical data on the risk for infectious diseases in individuals with diabetes while highlighting the mechanisms for altered immune regulation. The focus is on coronaviruses. Based on the new clinical data obtained from COVID-19 patients, a discussion of mechanisms, such as cytokine storm, pulmonary and endothelial dysfunction, and hypercoagulation, that may render individuals with diabetes more vulnerable to COVID-19 is provided.Major conclusions: Epidemiological studies show that poorly controlled diabetes is a risk factor for various infectious diseases. Given the global burden of diabetes and the pandemic nature of coronaviruses, understanding how diabetes affects COVID-19 severity is critical to designing tailored treatments and clinical management of individuals affected by diabetes.
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Publication type Article: Journal article
Document type Review
Keywords Diabetes ; Infection ; Coronavirus ; Covid-19 ; Sars-cov-2; Respiratory Syndrome Coronavirus; Adipose-tissue Macrophages; T-cells; Influenza Vaccination; Common Infections; Viral Load; Type-2; Comorbidities; Mellitus; Glucose
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 39, Issue: , Pages: , Article Number: 101044 Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
DOI 10.1016/j.molmet.2020.101044
WOS ID WOS:000562396800007
Scopus ID 85088987940
Scopus ID 85087184198
PubMed ID 32585364
Erfassungsdatum 2020-07-08
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