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Khan Mirzaei, M. ; Xue, J. ; Costa, R. ; Ru, J. ; Schulz, S. ; Taranu, Z.E.* ; Deng, L.

Challenges of studying the human virome – relevant emerging technologies.

Trends Microbiol. 29, 171-181 (2021)
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Open Access Hybrid
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In this review we provide an overview of current challenges and advances in bacteriophage research within the growing field of viromics. In particular, we discuss, from a human virome study perspective, the current and emerging technologies available, their limitations in terms of de novo discoveries, and possible solutions to overcome present experimental and computational biases associated with low abundance of viral DNA or RNA. We summarize recent breakthroughs in metagenomics assembling tools and single-cell analysis, which have the potential to increase our understanding of phage biology, diversity, and interactions with both the microbial community and the human body. We expect that these recent and future advances in the field of viromics will have a strong impact on how we develop phage-based therapeutic approaches.
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Publication type Article: Journal article
Document type Review
Keywords Bacteriophages ; Computational Tools ; Host Range ; Human Virome ; Multi-omics ; Phage De Novo Discoveries
Language english
Publication Year 2021
Prepublished in Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0966-842X
e-ISSN 1878-4380
Journal Trends in microbiology
Quellenangaben Volume: 29, Issue: 2, Pages: 171-181 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-554300-001
Grants European Research Council
German Reaserch Foundation (DFG Emmy Noether program)
DOI 10.1016/j.tim.2020.05.021
WOS ID WOS:000614460800010
Scopus ID 85087308722
Erfassungsdatum 2020-07-09
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