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Ovsepian, S.V. ; O´Leary, V.B.* ; Vesselkin, N.P.*

Evolutionary origins of chemical synapses.

In:. Amsterdam [u.a.]: Elsevier, 2020. 1-21 (Vitam. Horm. ; 114)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.
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Publication type Article: Edited volume or book chapter
Corresponding Author
Keywords Chemical Synapse ; Exaptation ; Functional Integration ; Gap Junctions ; Paracrine Signaling ; Snare Proteins ; Synaptic Evolution; Electrical Synapses; Gap-junctions; Postnatal-development; Neuronal Domains; Rat; Communication; Transmission; Release; Protein; Nerve
ISSN (print) / ISBN 0083-6729
e-ISSN 2162-2620
Journal Vitamins and Hormones
Quellenangaben Volume: 114, Issue: , Pages: 1-21 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants Charles University
MEYS under the NPU I program