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Ovsepian, S.V. ; O´Leary, V.B.* ; Vesselkin, N.P.*

Evolutionary origins of chemical synapses.

In:. Amsterdam [u.a.]: Elsevier, 2020. 1-21 (Vitam. Horm. ; 114)
DOI
Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.
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Publication type Article: Edited volume or book chapter
Keywords Chemical Synapse ; Exaptation ; Functional Integration ; Gap Junctions ; Paracrine Signaling ; Snare Proteins ; Synaptic Evolution; Electrical Synapses; Gap-junctions; Postnatal-development; Neuronal Domains; Rat; Communication; Transmission; Release; Protein; Nerve
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0083-6729
e-ISSN 2162-2620
Journal Vitamins and Hormones
Quellenangaben Volume: 114, Issue: , Pages: 1-21 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
Grants Charles University
MEYS under the NPU I program
DOI 10.1016/bs.vh.2020.04.009
WOS ID WOS:000612641100002
Scopus ID 85087395425
Erfassungsdatum 2020-07-21
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