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Korfei, M.* ; MacKenzie, B.* ; Meiners, S.

The ageing lung under stress.

Eur. Respir. Rev. 29:200126 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Healthy ageing of the lung involves structural changes but also numerous cell-intrinsic and cell-extrinsic alterations. Among them are the age-related decline in central cellular quality control mechanisms such as redox and protein homeostasis. In this review, we would like to provide a conceptual framework of how impaired stress responses in the ageing lung, as exemplified by dysfunctional redox and protein homeostasis, may contribute to onset and progression of COPD and idiopathic pulmonary fibrosis (IPF). We propose that age-related imbalanced redox and protein homeostasis acts, amongst others (e.g. cellular senescence), as a "first hit" that challenges the adaptive stress-response pathways of the cell, increases the level of oxidative stress and renders the lung susceptible to subsequent injury and disease. In both COPD and IPF, additional environmental insults such as smoking, air pollution and/or infections then serve as "second hits" which contribute to persistently elevated oxidative stress that overwhelms the already weakened adaptive defence and repair pathways in the elderly towards non-adaptive, irremediable stress thereby promoting development and progression of respiratory diseases. COPD and IPF are thus distinct horns of the same devil, "lung ageing".
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Endoplasmic-reticulum Stress; Obstructive Pulmonary-disease; Unfolded Protein Response; Impairs Proteasome Function; C/ebp Homologous Protein; Smoke-induced Emphysema; Oxidative Dna-damage; Cigarette-smoke; Er Stress; Cellular Senescence
ISSN (print) / ISBN 0905-9180
e-ISSN 1600-0617
Journal European Respiratory Review
Quellenangaben Volume: 29, Issue: 156, Pages: , Article Number: 200126 Supplement: ,
Publisher European Respiratory Society
Publishing Place 442 Glossop Rd, Sheffield S10 2px, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)