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Baumeister, S. ; Karch, A.* ; Bahls, M.* ; Teumer, A.* ; Leitzmann, M.F.* ; Baurecht, H.*

Physical activity and risk of Alzheimer disease A 2-sample mendelian randomization study.

Neurology 95, E1897-E1905 (2020)
Postprint DOI PMC
Open Access Green
Objective Evidence from observational studies for the effect of physical activity on the risk of Alzheimer disease (AD) is inconclusive. We performed a 2-sample mendelian randomization analysis to examine whether physical activity is protective for AD. Methods Summary data of genome-wide association studies on physical activity and AD were used. The primary study population included 21,982 patients with AD and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNPs) known atp< 5 x 10(-8)to be associated with average accelerations and 8 SNPs associated atp< 5 x 10(-7)with vigorous physical activity (fraction of accelerations >425 milligravities) served as instrumental variables. Results There was no association between genetically predicted average accelerations with the risk of AD (inverse variance weighted odds ratio [OR] per SD increment: 1.03, 95% confidence interval 0.97-1.10,p= 0.332). Genetic liability for fraction of accelerations >425 milligravities was unrelated to AD risk. Conclusion The present study does not support a causal association between physical activity and risk of AD.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Dementia; Metaanalysis; Diet
ISSN (print) / ISBN 0028-3878
e-ISSN 1526-632X
Journal Neurology
Quellenangaben Volume: 95, Issue: 13, Pages: E1897-E1905 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Independent Research Group Clinical Epidemiology (KEPI)
Grants Alzheimer's Association
Wellcome Trust
Alzheimer's Research UK
Medical Research Council
Universite de Lille 2
Lille University Hospital
Institut Pasteur de Lille
Inserm
LABEX (Laboratory of Excellence Program Investment for the Future) DISTALZ grant
German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND)
Erasmus University
Erasmus Medical Center
Icelandic Heart Association
NHLBI
AGES contract
NIA
NIH/NIA
French National Foundation on Alzheimer's Disease and Related Disorders