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Pyrina, I.* ; Chung, K.J.* ; Michailidou, Z.* ; Koutsilieris, M.* ; Chavakis, T. ; Chatzigeorgiou, A.*

Fate of adipose progenitor cells in obesity-related chronic inflammation.

Front. Cell Dev. Biol. 8:644 (2020)
Publ. Version/Full Text DOI PMC
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Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates, contributing to white and beige adipogenesis, fibrosis or maintenance of an immature cell phenotype with proliferation capacity. Mature adipocytes as well as cells of the immune system residing in the adipose tissue can modulate the function and differentiation potential of preadipocytes in a contact- and/or paracrine-dependent manner. In the course of obesity, the accumulation of immune cells within the adipose tissue contributes to the development of a pro-inflammatory microenvironment in the tissue. Under such circumstances, the crosstalk between preadipocytes and immune or parenchymal cells of the adipose tissue may critically regulate the differentiation of preadipocytes into white adipocytes, beige adipocytes, or myofibroblasts, thereby influencing adipose tissue expansion and adipose tissue dysfunction, including downregulation of beige adipogenesis and development of fibrosis. The present review will outline the current knowledge about factors shaping cell fate decisions of adipose progenitor cells in the context of obesity-related inflammation.
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Publication type Article: Journal article
Document type Review
Keywords Preadipocyte ; Adipose Progenitor ; Inflammation ; Adipogenesis ; Beiging ; Obesity ; Fibrosis; Alternatively Activated Macrophages; Adipocyte Differentiation; Tissue Inflammation; Beige Adipocytes; Immune Cells; Adipogenesis; Identification; Alpha; Brown; Interleukin-1-beta
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2296-634X
e-ISSN 2296-634X
Journal Frontiers in cell and developmental biology
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 644 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-008
Grants German Research Foundation (DFG)
DOI 10.3389/fcell.2020.00644
WOS ID WOS:000556363100001
Scopus ID 85088798891
PubMed ID 32760729
Erfassungsdatum 2020-10-07
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