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Innovative HBV animal models based on the entry receptor NTCP.
Viruses 12:828 (2020)
Hepatitis B is a major global health problem, with an estimated 257 million chronically infected patients and almost 1 million deaths per year. The causative agent is hepatitis B virus (HBV), a small, enveloped, partially double-stranded DNA virus. HBV has a strict species specificity, naturally infecting only humans and chimpanzees. Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter expressed on hepatocytes, has been shown to be one of the key factors in HBV infection, playing a crucial role in the HBV entry process in vitro and in vivo. Variations in the amino acid sequence of NTCP can inhibit HBV infection and, therefore, contributes, in part, to the species barrier. This discovery has revolutionized the search for novel animal models of HBV. Indeed, it was recently shown that variations in the amino acid sequence of NTCP represent the sole species barrier for HBV infection in macaques. Here, we review what is known about HBV entry through the NTCP receptor and highlight how this knowledge has been harnessed to build new animal models for the study of HBV pathogenesis and curative therapies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Sodium Taurocholate Co-transporting Polypeptide ; Hepatitis B Virus ; Rhesus Macaque ; Animal Model; Hepatitis-b-virus; Cyclosporine-a; Woolly Monkey; Delta Virus; Infection; Hepatocytes; Replication; Transporter; Binding; Mice
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1999-4915
e-ISSN
1999-4915
Journal
Viruses
Quellenangaben
Volume: 12,
Issue: 8,
Article Number: 828
Publisher
MDPI
Publishing Place
St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Immune Response and Infection
PSP Element(s)
G-502700-003
WOS ID
WOS:000578975500001
Scopus ID
85089132344
PubMed ID
32751581
Erfassungsdatum
2020-10-09