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Geng, X.* ; Babayeva, L.* ; Walch, A.K. ; Aubele, M. ; Gross, E.* ; Kiechle, M.* ; Bronger, H.* ; Dreyer, T.* ; Magdolen, V.* ; Dorn, J.*

High levels of KLK7 protein expression are related to a favorable prognosis in triple-negative breast cancer patients.

Am. J. Cancer Res. 10, 1785-1792 (2020)

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PMC

	Open Access Gold (Paid Option)

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In normal physiology, kallikrein-related peptidase 7 (KLK7), together with other members of the kallikrein-related peptidase family, is mainly involved in skin desquamation and keratinization processes. Moreover, expression of KLK7 was shown in various tumor types to be dysregulated and to correlate to patients' survival time. However, there are contradictory reports in breast cancer whether KLK7 represents an unfavorable or favorable prognostic biomarker. In the present study, we examined the prognostic value of KLK7 protein expression in triple-negative breast cancer (TNBC), determined by immunohistochemistry (IHC). A cohort encompassing 133 TNBC specimens, present on tissue microarrays, was analyzed. For quantification of the staining intensity, an automated digital IHC image analysis algorithm was applied. In both Kaplan-Meier and univariate Cox analyses, elevated KLK7 protein levels were significantly linked with prolonged overall survival (OS). In multivariable Cox analysis, addition of KLK7 immunoreactivity scores to the base model (including the clinical parameters age, tumor size, and nodal status) demonstrated that KLK7 protein expression remained as a statistically significant, independent parameter for prolonged OS. These results strongly indicate that KLK7 is a favorable prognostic biomarker in triple negative breast cancer.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Triple-negative Breast Cancer ; Kallikrein-related Peptidase ; Klk7 ; Prognostic Marker ; Clinical Relevance; Messenger-rna Expression; Peptidase 7 Klk7; Gene-expression; Poor-prognosis; Kallikrein-7; Relevance; Family

e-ISSN 2156-6976

Journal American Journal of Cancer Research

Quellenangaben Volume: 10, Issue: 6, Pages: 1785-1792

Publisher e-Century Publ.

Publishing Place Madison, Wis.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Analytical Pathology (AAP)