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Hindelang, B. ; Aguirre Bueno, J. ; Berezhnoi, A. ; Biedermann, T.* ; Darsow, U.* ; Eberlein, B.* ; Ntziachristos, V.

Quantification of skin sensitivity to ultraviolet radiation using ultra-wideband optoacoustic mesoscopy.

Br. J. Dermatol., DOI: 10.1111/bjd.19463 (2020)

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Phototesting is used to assess individual sensitivity to ultraviolet (UV) radiation in order to determine adequate UV dosage for phototherapy¹ . In the standard procedure, small skin areas are exposed to increasing doses of UV radiation. The lowest UV dose that induces a delineated erythema at 24±2 h after UV exposure defines the minimal erythema dose (MED)² . Visual assessment is the gold standard for MED determination; however, it is prone to observer variability³ . Optical methods have been considered to quantify the magnitude of erythema response. However, they are limited by light scattering therefore high-resolution is restricted to depths of <200 μm resulting in unreliable measurements^4,5 .

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