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Prävention von Asthma im Kindesalter. Was bedeutet der Bauernhofeffekt für die Praxis?
Prevention of childhood asthma-What does the farm effect mean in clinical practice?
Mon.schr. Kinderheilkd. 168, 988–994 (2020)
The prevalence of childhood asthma is increasing worldwide. Industrial nations are particularly affected by this development. The complexity of the disease, the genesis of which depends on numerous endogenous and exogenous factors, makes it difficult to decipher the causes of this worrying development. With the emergence of the hygiene hypothesis some 30 years ago, which postulated the decline in microbial stimulation by infections as a risk factor, numerous influencing factors were examined. In large-scale farm studies, animal husbandry and consumption of untreated dairy products could be identified as preventive factors. The underlying pathomechanism was described as stimulation and regulation of the immune system in its prenatal and postnatal development through microbial diversity, allergen and endotoxin exposure as well as the special composition of untreated cow's milk. While exposure to protective substances in the environment has not yet found its way into everyday clinical practice due to the numerous influencing components and the difficult feasibility, the findings on untreated or partially treated dairy products play an increasing role as possible strategies in the prevention of childhood asthma.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hygiene Hypothesis ; Animal Husbandry ; Milk ; Immunmodulation ; Microbial Exposure; Regulatory T-cells; Exposure; Maturation; Children; Allergy
ISSN (print) / ISBN
0026-9298
e-ISSN
1433-0474
Journal
Monatsschrift Kinderheilkunde
Quellenangaben
Volume: 168,
Pages: 988–994
Publisher
Springer
Publishing Place
One New York Plaza, Suite 4600, New York, Ny, United States
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)