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Storz, C.* ; Rospleszcz, S. ; Askani, E.* ; Rothenbacher, T.* ; Linseisen, J. ; Messmann, H.* ; De Cecco, C.N.* ; Machann, J. ; Kiefer, L.S.* ; Elser, S.* ; Rathmann, W.* ; Peters, A. ; Schlett, C.L.* ; Bamberg, F.*

Magnetic resonance imaging of diverticular disease and its association with adipose tissue compartments and constitutional risk factors in subjects from a western general population.

Rofo-Fortschr. Rontg. 193, 33-41 (2021)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Purpose To determine the association of asymptomatic diverticular disease as assessed by magnetic resonance imaging (MRI) with adipose tissue compartments, hepatic steatosis and constitutional risk factors within a cohort drawn from a Western general population. Materials and Methods Asymptomatic subjects enrolled in a prospective case-control study underwent a 3 Tesla MRI scan, including an isotropic VIBE-Dixon sequence of the entire trunk. The presence and extent of diverticular disease were categorized according to the number of diverticula in each colonic segment in a blinded fashion. The amount of visceral, subcutaneous, and total adipose tissue (VAT, SAT, and TAT) was quantified by MRI. Additionally, the degree of hepatic steatosis, indicated as hepatic proton density fat fraction (hepatic PDFF) was determined using a multi-echo T1w sequence. Constitutional cardiometabolic risk factors were obtained and univariate and multivariate associations were calculated. Results A total of 371 subjects were included in the analysis (58.2% male, 56.2±9.2 years). Based on MRI, 154 participants (41.5%) had diverticular disease with 62 cases (17%) being advanced diverticular disease. Subjects with advanced diverticular disease had a significantly higher body mass index (BMI) (BMI: 29.9±5.1 vs. 27.5±4.6, p<0.001; respectively). Furthermore, all adipose tissue compartments were increased in subjects with advanced diverticular disease (e.g. VAT: 6.0±2.8 vs. 4.2±2.6 and SAT: 9.2±3.6 vs. 7.8±3.6, all p<0.001, respectively). Similarly, subjects with advanced diverticular disease had significantly higher hepatic PDFF (4.9 [2.7, 11.4] vs. 6.1 [5.5, 14.6], p=0.002). Conclusion Advanced diverticular disease is associated with an increased volume of adipose tissue compartments and BMI, which may suggest a metabolic role in disease development. Key Points: Diverticular disease is associated with constitutional risk factors such as BMI. Excess of adipose tissue compartments and hepatic steatosis are associated with the prevalence of diverticular disease. Our results suggest a shared pathological pathway of cardiometabolic alterations and the prevalence of diverticular disease. MRI is feasible for the assessment of adipose tissue compartments, hepatic steatosis, and diverticular disease and allows identification of patients who are at risk but in an asymptomatic disease state. Citation Format Storz C, Rospleszcz S, Askani E etal. Magnetic Resonance Imaging of Diverticular Disease and its Association with Adipose Tissue Compartments and Constitutional Risk Factors in Subjects from a Western General Population. Fortschr Röntgenstr 2020; DOI: 10.1055/a-1212-5669.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Abdomen ; Diverticular Disease ; Epidemiology ; Metabolic Disorders ; Mri; Fatty Liver; Colonic Diverticulosis; Cardiovascular-disease; Metabolic Syndrome; Obesity; Adipocytokines; Kora
ISSN (print) / ISBN 1438-9029
e-ISSN 1438-9010
Journal Fortschritte auf dem Gebiet der Röntgenstrahlen und der Bildgebenden Verfahren
Quellenangaben Volume: 193, Issue: 01, Pages: 33-41 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Stuttgart
Non-patent literature Publications
Institute(s) Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants German Centre for Cardiovascular Disease Research
Deutsche Forschungsgemeinschaft
German Centre for Diabetes Research, Neuherberg
German Federal Ministry of Education and Research BMBF