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Choi, H.S.* ; Ashitate, Y.* ; Lee, J.H.* ; Kim, S.H.* ; Matsui, A.* ; Insin, N.* ; Bawendi, M.G.* ; Semmler-Behnke, M. ; Frangioni, J.V.* ; Tsuda, A.*

Rapid translocation of nanoparticles from the lung airspaces to the body.

Nat. Biotechnol. 28, 1300-1303 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes. Nanoparticles of HD < 6 nm can traffic rapidly from the lungs to lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys. We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 1087-0156
e-ISSN 1546-1696
Journal Nature Biotechnology
Quellenangaben Volume: 28, Issue: 12, Pages: 1300-1303 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
PSP Element(s) G-505000-002
G-505000-005
PubMed ID 21057497
DOI 10.1038/nbt.1696
Scopus ID 78650012703
Erfassungsdatum 2010-12-03
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