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Kuiper, I.N.* ; Markevych, I. ; Accordini, S.* ; Bertelsen, R.J.* ; Bråbäck, L.* ; Christensen, J.H.* ; Forsberg, B.* ; Halvorsen, T.* ; Heinrich, J.* ; Hertel, O.* ; Hoek, G.* ; Holm, M.* ; de Hoogh, K.* ; Janson, C.* ; Malinovschi, A.* ; Marcon, A.* ; Sigsgaard, T.* ; Svanes, C.* ; Johannessen, A.*

Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever.

Int. J. Environ. Res. Public Health 17:5828 (2020)

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We investigated if greenness and air pollution exposure in parents' childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM(2.5)and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O-3) (mu g/m(3)) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0-18 years old and offspring 0-10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM(2.5)and PM(10)exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32-3.78, OR 2.27, 95%CI 1.36-3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11-0.87). Hay fever risk increased for offspring of fathers with medium O(3)exposure (OR 4.15, 95%CI 1.28-13.50) and mothers with high PM(10)exposure (OR 2.66, 95%CI 1.19-5.91). The effect of maternal PM(10)exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring's own exposures. Paternal O(3)exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Air Pollution ; Greenness ; Preconception Exposure ; Childhood Asthma ; Childhood Hay Fever; Residential Greenness; Childhood Asthma; Children; No2; Greenspace; Mortality; Benefits; Smoking; Europe; Models

ISSN (print) / ISBN 1661-7827

e-ISSN 1660-4601

Journal International Journal of Environmental Research and Public Health

Quellenangaben Volume: 17, Issue: 16, Article Number: 5828

Publisher MDPI

Publishing Place Basel, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)

Grants Swedish Asthma and Allergy Association
Swedish Heart-Lung Foundation
Norwegian Asthma and Allergy Association
World University Network
Bergen Medical Research Foundation
Research Council of Norway
European Union's Horizon 2020 research and innovation program as part of the ALEC (Ageing Lungs in European Cohorts study)
Western Norway Regional Health Authorities