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Metabolically healthy and unhealthy normal weight and obesity.
Endocrinol. Metab. 35, 487–493 (2020)
Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality. However, also very low fat mass associates with such an increased risk. Whether impaired metabolic health, characterized by hypertension, dyslipidemia, hyperglycemia, insulin resistance, and subclinical inflammation, may explain part of the elevated risk of cardiometabolic diseases that is found in many subjects with very low fat mass, as it does in many obese subjects, is unknown. An important pathomechanism of impaired metabolic health is disproportionate fat distribution. In this article the risk of cardiometabolic diseases and mortality in subjects with metabolically healthy and unhealthy normal weight and obesity is summarized. Furthermore, the change of metabolic health during a longer period of follow-up and its impact on cardiometabolic diseases is being discussed. Finally, the implementation of the concept of metabolic health in daily clinical practice is being highlighted.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
3.257
1.212
2
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Publication type
Article: Journal article
Document type
Review
Keywords
Fatty Liver ; Insulin Resistance ; Metabolic Health ; Normal Weight ; Obesity ; Obesity, Abdominal ; Subclinical Inflammation; All-cause; Fetuin-a; Disease; Risk; Overweight; Consequences; Association; Phenotypes; Mortality; Genetics
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
2093-596X
e-ISSN
2093-5978
Journal
Endocrinology and Metabolism
Quellenangaben
Volume: 35,
Issue: 3,
Pages: 487–493
Publisher
Korean Endocrine Society
Publishing Place
Seoul
Reviewing status
Peer reviewed
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502400-001
Grants
German Federal Ministry of Education and Research to the German Centre of Diabetes Researc
WOS ID
WOS:000596724400001
PubMed ID
32814419
Erfassungsdatum
2020-10-20