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Morphometric cell classification for single-Cell MALDI-mass spectrometry imaging.
Angew. Chem.-Int. Edit. 132, 17600-17603 (2020)
The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
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Times Cited
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12.959
2.254
6
27
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Imaging ; Lipids ; Mass Spectrometry ; Morphometry ; Single-cell Analysis
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1433-7851
e-ISSN
1521-3773
Quellenangaben
Volume: 132,
Issue: 40,
Pages: 17600-17603
Publisher
Wiley
Publishing Place
Weinheim
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical Pathology (AAP)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-500390-001
WOS ID
WOS:000559988300001
Scopus ID
85089466155
PubMed ID
32668069
Erfassungsdatum
2020-09-15