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Morphometric cell classification for single-Cell MALDI-mass spectrometry imaging.
Angew. Chem.-Int. Edit. 132, 17600-17603 (2020)
Publ. Version/Full Text
Research data
DOI
PMC
The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Imaging ; Lipids ; Mass Spectrometry ; Morphometry ; Single-cell Analysis
ISSN (print) / ISBN
1433-7851
e-ISSN
1521-3773
Quellenangaben
Volume: 132,
Issue: 40,
Pages: 17600-17603
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical Pathology (AAP)