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Katsimpris, A.* ; Jürgens, C.* ; Lüdtke, L.* ; Martin, B.* ; Ittermann, T.* ; Gläser, S.* ; Dörr, M.* ; Ewert, R.* ; Volaklis, K.* ; Felix, S.B.* ; Tost, F.* ; Völzke, H.* ; Meisinger, C. ; Baumeister, S.

Association between cardiorespiratory fitness and handgrip strength with age-related macular degeneration: A population-based study.

Brit. J. Ophthal. 105, 1127-1132 (2020)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Aim: To assess whether cardiorespiratory fitness (CRF) and handgrip strength, two objective markers of physical fitness, are associated with age-related macular degeneration (AMD). Methods: We analysed cross-sectional data from the population-based Study of Health in Pomerania (2008-2012) including 1173 adult men and women aged 20-79 years. Fundus photography of the central retina was recorded with a non-mydriatic camera, and images were graded according to an established clinical AMD classification scale by an experienced reader. CRF was measured using peak oxygen uptake (peakVO2), oxygen uptake at the anaerobic threshold (VO2@AT), and maximum power output (Wmax) from standardised cardiopulmonary exercise testing on a bicycle ergometer according to a modified Jones protocol. Handgrip strength was assessed using a handheld dynamometer. Adjusted prevalence ratios (PR) for the associations of peakVO2, VO2@AT, Wmax and handgrip strength with AMD were derived from multivariable Poisson regression models. Results: PeakVO2, VO2@AT, Wmax and handgrip strength were not associated with AMD. Adjusted PR for AMD associated with a 1-SD increment in peakVO2, VO2@AT, Wmax and handgrip strength were 1.05 (95% CI 0.82 to 1.34), 0.96 (95% CI 0.78 to 1.18), 1.10 (95% CI 0.86 to 1.41) and 1.01 (95% CI 0.79 to 1.30), respectively. These associations were not modified by age, sex, smoking, body mass index and diabetes. Estimates in sensitivity analysis for confounding, selection bias and missing data were similar. Conclusion: In our study, CRF and handgrip strength were not associated with AMD. Nevertheless, longitudinal studies with bigger sample sizes are needed to furtherly examine these associations.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Degeneration ; Epidemiology ; Macula; Inverse Probability Weights; Physical-activity; Blood-pressure; Exercise; Risk; Health; Overweight
ISSN (print) / ISBN 0007-1161
e-ISSN 1468-2079
Journal British Journal of Ophthalmology
Quellenangaben Volume: 105, Issue: 8, Pages: 1127-1132 Article Number: , Supplement: ,
Publisher British Medical Association
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Independent Research Group Clinical Epidemiology (KEPI)
Grants Ministry for Social Affairs of the State Mecklenburg-West Pomerania
Ministry for Education, Research and Cultural Affairs
German Federal Ministry for education and research (BMBF)