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Metwaly, A.* ; Dunkel, A.* ; Waldschmitt, N.* ; Durai Raj, A.C. ; Lagkouvardos, I.* ; Corraliza, A.M.* ; Mayorgas, A.* ; Martinez-Medina, M.* ; Reiter, S.* ; Schloter, M. ; Hofmann, T.* ; Allez, M.* ; Panes, J.* ; Salas, A.* ; Haller, D.*

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism.

Nat. Commun. 11:4322 (2020)
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Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn’s disease patients undergoing autologous hematopoietic stem cell transplantation, and investigational therapy that induces drug free remission in a subset of patients. Via comparison of patients who responded and maintained remission, responded but experienced disease relapse and patients who did not respond to therapy, we identify shared functional signatures that correlate with disease activity despite the variability of gut microbiota profiles at taxonomic level. These signatures reflect the disease state when transferred to gnotobiotic mice. Taken together, the integration of microbiome and metabolite profiles from human cohort and mice improves the predictive modelling of disease outcome, and allows the identification of a network of bacteria-metabolite interactions involving sulfur metabolism as a key mechanism linked to disease activity in Crohn’s disease.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Stem-cell Transplantation; Gut Microbiome; Functional-characterization; Bacteria; Inflammation; Dysbiosis; Sequences; Therapy; Toxin
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 4322 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Comparative Microbiome Analysis (COMI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
PSP Element(s) G-504700-002
Grants Projekt DEAL
Helmsley Charitable Trust (IBDOT)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
Leona and Harry Helmsley Charitable Trust (IBDOT Consortium)
DOI 10.1038/s41467-020-17956-1
WOS ID WOS:000607079100007
Scopus ID 85089980837
PubMed ID 32859898
Erfassungsdatum 2020-10-22
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