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Global variability of the human IgG glycome.
Aging 12, 15222-15259 (2020)
Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG's fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
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Cited By
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4.831
1.162
5
13
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Aging ; Fc Glycosylation ; Glycans ; Immunoglobulin G ; Mass Spectrometry
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1945-4589
e-ISSN
1945-4589
Journal
Aging
Quellenangaben
Volume: 12,
Issue: 15,
Pages: 15222-15259
Publisher
Impact Journals LLC
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504091-004
WOS ID
WOS:000567845800004
Scopus ID
85090177105
PubMed ID
32788422
Erfassungsdatum
2020-09-18