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Rajewsky, N.* ; Almouzni, G.* ; Gorski, S.A.* ; Aerts, S.* ; Amit, I.* ; Bertero, M.G.* ; Bock, C.* ; Bredenoord, A.L.* ; Cavalli, G.* ; Chiocca, S.* ; Clevers, H.* ; de Strooper, B.* ; Eggert, A.* ; Ellenberg, J.* ; Fernández, X.M.* ; Figlerowicz, M.* ; Gasser, S.M.* ; Hubner, N.* ; Kjems, J.* ; Knoblich, J.A.* ; Krabbe, G.* ; Lichter, P.* ; Linnarsson, S.* ; Marine, J.C.* ; Marioni, J.* ; Marti-Renom, M.A.* ; Netea, M.G.* ; Nickel, D.* ; Nollmann, M.* ; Novak, H.R.* ; Parkinson, H.* ; Piccolo, S.* ; Pinheiro, I.* ; Pombo, A.* ; Popp, C.* ; Reik, W.* ; Roman-Roman, S.* ; Rosenstiel, P.* ; Schultze, J.L.* ; Stegle, O.* ; Tanay, A.* ; Testa, G.* ; Thanos, D.* ; Theis, F.J. ; Torres-Padilla, M.E. ; Valencia, A.* ; Vallot, C.* ; van Oudenaarden, A.* ; Vidal, M.* ; Voet, T.* ; LifeTime Community (Schiller, H. B.) ; LifeTime Community (Ziegler, A.-G.)

LifeTime and improving European healthcare through cell-based interceptive medicine.

Nature 587, 377–386 (2020)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Alzheimers-disease; Gene-expression; Omics; Reconstruction; Reveals; Brain
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 587, Issue: , Pages: 377–386 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Institute of Epigenetics and Stem Cells (IES)
Lung Health and Immunity (LHI)
Institute of Diabetes Research Type 1 (IDF)
Grants European Union