PuSH - Publication Server of Helmholtz Zentrum München: Four‐year follow‐up of [<sup>18</sup>F]fluorodeoxyglucose positron emission tomography–based Parkinson disease–related pattern expression in 20 patients with isolated rapid eye movement sleep behavior disorder shows prodromal progression.

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Kogan, R.V.* ; Janzen, A.* ; Meles, S.K.* ; Sittig, E.* ; Renken, R.J.* ; Gurvits, V.* ; Mayer, G.* ; Leenders, K.L.* ; Oertel, W.H.

Four‐year follow‐up of [¹⁸F]fluorodeoxyglucose positron emission tomography–based Parkinson disease–related pattern expression in 20 patients with isolated rapid eye movement sleep behavior disorder shows prodromal progression.

Mov. Disord. 36, 230-235 (2021)

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Background: Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha-synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [F-18]fluorodeoxyglucose-positron emission tomography (PET)-based PD-related brain pattern can be used to monitor disease progression.Objective: We longitudinally investigated PD-related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters.Methods: Subjects underwent two [F-18]fluorodeoxyglucose-PET brain scans similar to 3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame.Results: At baseline, 8 of 20 (40%) subjects significantly expressed the PD-related brain pattern (withzscores above the receiver operating characteristic-determined threshold). At follow-up, six additional subjects exhibited significant PD-related brain pattern expression (70% in total). PD-related brain pattern expression increased in all subjects (P=0.00008). Four subjects (20%), all with significant baseline PD-related brain pattern expression, phenoconverted to clinical PD.Conclusions: Suprathreshold PD-related brain pattern expression and greater score rate of change may signify greater shorter-term risk for phenoconversion. Our results support the use of serial PD-related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords [f-18]fdg-pet ; Rapid Eye Movement Sleep Behavior Disorder ; Parkinson's Disease-related Pattern ; Neuroimaging ; Prodromal Progression Biomarker; Montreal Cognitive Assessment; Metabolic Network Activity; Dementia; Spect; Tool

ISSN (print) / ISBN 0885-3185

e-ISSN 1531-8257

Journal Movement Disorders

Quellenangaben Volume: 36, Issue: 1, Pages: 230-235

Publisher Wiley

Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Neurogenomics (ING)

Grants Stichting ParkinsonFonds
ParkinsonFonds Deutschland

PuSH - Publication Server of Helmholtz Zentrum München

Four‐year follow‐up of [18F]fluorodeoxyglucose positron emission tomography–based Parkinson disease–related pattern expression in 20 patients with isolated rapid eye movement sleep behavior disorder shows prodromal progression.

Four‐year follow‐up of [¹⁸F]fluorodeoxyglucose positron emission tomography–based Parkinson disease–related pattern expression in 20 patients with isolated rapid eye movement sleep behavior disorder shows prodromal progression.