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Käsmann, L.* ; Dietrich, A.* ; Staab-Weijnitz, C.A. ; Manapov, F.* ; Behr, J.* ; Rimner, A.* ; Jeremic, B.* ; Senan, S.* ; De Ruysscher, D.* ; Lauber, K.* ; Belka, C.*

Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.

Radiat. Oncol. 15:214 (2020)

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	Open Access Gold

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Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Obliterans Organizing Pneumonia; Breast-cancer Patients; Hyperfractionated Radiation; Concurrent Chemotherapy; Thoracic Radiotherapy; European-organization; Clinical-features; Tumor Volume; Risk-factors; Stem-cells

ISSN (print) / ISBN 1748-717X

e-ISSN 1748-717X

Journal Radiation Oncology

Quellenangaben Volume: 15, Issue: 1, Article Number: 214

Publisher BioMed Central

Publishing Place Campus, 4 Crinan St, London N1 9xw, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Lung Health and Immunity (LHI)

Grants NIH/NCI Cancer Center Support Grant
BMBF
DFG
German Cancer Consortium (DKTK)
CPC-M translational funds (German Center for Lung Research (DZL))
Munich Excellence Training Initiative for Physician Scientists (Metiphys)