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Primary prevention of asthma: From risk and protective factors to targeted strategies for prevention.
Lancet 396, 854-866 (2020)
Asthma is a complex disease that often starts in childhood. Genomic and environmental factors as well as aberrant immune maturation early in life can contribute to the onset of disease, with great disparity over time and geographical regions. Epidemiological studies have scrutinised environmental exposures and attempted to translate these exposures into prevention strategies. Some approaches for patients with asthma have been successful (eg, smoking ban, the Finnish Asthma Programme), and primary prevention of wheeze in pre-school children (age 0-5 years) by the supplementation of vitamin D or fish oil, or both, to pregnant women seems promising. Several recent prevention initiatives are based on strong asthma-protective environmental microbial exposures associated with traditional rural lifestyles. Preclinical studies with various bacterial lysates, bacterial and dietary metabolites, or helminthic compounds have yielded promising results that await translation into clinical practice. Given the immense societal and individual burden of asthma, there is an urgent need to further develop novel strategies to eradicate the disease.
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Publication type
Article: Journal article
Document type
Review
Keywords
Childhood Asthma; Respiratory Microbiota; Genetic Susceptibility; Airway Inflammation; Randomized-trial; Vitamin-d; Wheeze; Children; Allergy; Health
ISSN (print) / ISBN
0140-6736
e-ISSN
0099-5355
Journal
Lancet, The
Quellenangaben
Volume: 396,
Issue: 10254,
Pages: 854-866
Publisher
Elsevier
Publishing Place
Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)