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Glaser, C.* ; Demmelmair, H.* ; Sausenthaler, S. ; Herbarth, O.* ; Heinrich, J. ; Koletzko, B.*

Fatty acid composition of serum glycerophospholipids in children.

J. Pediatr. 157, 826-831 (2010)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Objective To determine reference values for fatty acid (FA) composition of serum glycerophospholipids (GPs) in children with a new high-throughput method. Study design The GP FA composition of 1326 serum samples obtained from a cohort of 951 children at 2 and 6 years, participating in the German Influences of Lifestyle Related Factors on the Immune Systemand the Development of Allergies in Childhood (LISA) study, was analyzed with a new high-throughput method. Only 2 simple preparation steps were necessary to obtain fatty acid methyl esters selectively from serum GPs. The FA status was determined by separating and quantifying the fatty acid methyl esters with high-resolution capillary gas chromatography. Results FA values in serum GPs were in very good agreement with other published values in serum or plasma phospholipids for most of the analyzed FAs. No major age and sex differences in GP FA composition were observed. Conclusion The serum GP FA values obtained from children aged 2 and 6 years may serve as reference values in clinical practice (eg, for monitoring and improving therapeutic interventions). Furthermore, they can serve as a reference point for interpreting FA values in clinical and epidemiological studies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords HEALTHY-SUBJECTS; YOUNG ADULTHOOD; CYSTIC-FIBROSIS; DIETARY-INTAKE; BIRTH COHORT; GENE-CLUSTER; HUMAN PLASMA; BLOOD-CELLS; PHOSPHOLIPIDS; LIPIDS
ISSN (print) / ISBN 0022-3476
e-ISSN 1097-6833
Journal Journal of Pediatrics, The
Quellenangaben Volume: 157, Issue: 5, Pages: 826-831 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)