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Conrad, M. ; Lorenz, S. ; Proneth, B.

Targeting ferroptosis: New hope for as-yet-incurable diseases.

Trends Mol. Med. 27, 113-122 (2021)
Postprint DOI
Open Access Green
Attaining control over life and death decisions facilitates the identification of new therapeutic strategies for diseases affected by early cell loss or resistance to cell death. In this context, ferroptosis, a prevailing form of non-apoptotic cell death marked by the iron-dependent oxidative destruction of lipid bilayers and metabolic aberrations, has attracted overwhelming interest among basic researchers and clinicians due to its relevance for a number of degenerative diseases, such as neurodegeneration, ischemia/reperfusion injury (IRI), and organ failure, as well as therapy-resistant tumors. As the ferroptotic death pathway offers various druggable nodes, it is anticipated that the preclinical and clinical development of ferroptosis modulators will unleash unprecedented opportunities for the treatment of as-yet-incurable diseases.
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Publication type Article: Journal article
Document type Review
Keywords Cancer ; Ischemia/reperfusion Injury ; Lipid Peroxidation ; Necroinflammation ; Neurodegeneration ; Regulated Necrosis
Language english
Publication Year 2021
Prepublished in Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 1471-4914
e-ISSN 1471-499X
Journal Trends in Molecular Medicine
Quellenangaben Volume: 27, Issue: 2, Pages: 113-122 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
Institute(s) Institute of Metabolism and Cell Death (MCD)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-506900-001
Grants Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi)
Else Kroner-Fresenius-Stiftung
Ministry of Science and Higher Education of The Russian Federation
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Deutsche Forschungsgemeinschaft (DFG)
DOI 10.1016/j.molmed.2020.08.010
WOS ID WOS:000615867700005
Scopus ID 85091247804
Erfassungsdatum 2020-11-09
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