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Conrad, M. ; Lorenz, S. ; Proneth, B.

Targeting ferroptosis: New hope for as-yet-incurable diseases.

Trends Mol. Med. 27, 113-122 (2021)

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	Open Access Green

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Attaining control over life and death decisions facilitates the identification of new therapeutic strategies for diseases affected by early cell loss or resistance to cell death. In this context, ferroptosis, a prevailing form of non-apoptotic cell death marked by the iron-dependent oxidative destruction of lipid bilayers and metabolic aberrations, has attracted overwhelming interest among basic researchers and clinicians due to its relevance for a number of degenerative diseases, such as neurodegeneration, ischemia/reperfusion injury (IRI), and organ failure, as well as therapy-resistant tumors. As the ferroptotic death pathway offers various druggable nodes, it is anticipated that the preclinical and clinical development of ferroptosis modulators will unleash unprecedented opportunities for the treatment of as-yet-incurable diseases.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Cancer ; Ischemia/reperfusion Injury ; Lipid Peroxidation ; Necroinflammation ; Neurodegeneration ; Regulated Necrosis

ISSN (print) / ISBN 1471-4914

e-ISSN 1471-499X

Journal Trends in Molecular Medicine

Quellenangaben Volume: 27, Issue: 2, Pages: 113-122

Publisher Elsevier

Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Metabolism and Cell Death (MCD)

Grants Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi)
Else Kroner-Fresenius-Stiftung
Ministry of Science and Higher Education of The Russian Federation
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Deutsche Forschungsgemeinschaft (DFG)