PuSH - Publication Server of Helmholtz Zentrum München: Effect of the pharmaceuticals diclofenac and lamotrigine on stress responses and stress gene expression in lettuce (<em>Lactuca sativa</em>) at environmentally relevant concentrations.

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Bigott, Y. ; Chowdhury, S.P. ; Pérez, S.* ; Montemurro, N.* ; Manasfi, R.* ; Schröder, P.

Effect of the pharmaceuticals diclofenac and lamotrigine on stress responses and stress gene expression in lettuce (Lactuca sativa) at environmentally relevant concentrations.

J. Hazard. Mater. 403:123881 (2021)

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Vegetable crops irrigated with treated wastewater can take up the environmentally persistent pharmaceuticals diclofenac and lamotrigine. This study aimed at quantifying the uptake and translocation of the two pharmaceuticals in lettuce (Lactuca sativa) as well as on the elucidation of the molecular and physiological changes triggered by them. Therefore, plants were cultivated in a phytochamber in hydroponic systems under controlled conditions and treated independently with diclofenac (20 μg L−1) and lamotrigine (60 μg L−1) for 48 h. A low translocation of lamotrigine but not of diclofenac or its metabolite 4’-hydroxydiclofenac to leaves was observed, which corresponded with the expression of stress related genes only in roots of diclofenac treated plants. We observed an oxidative burst in roots and leaves occurring around the same time point when lamotrigine was detected in leaves. This could be responsible for the significantly changed gene expression pattern in both tissues. Our results showed for the first time that pharmaceuticals like lamotrigine or diclofenac might act as signals or zeitgebers, affecting the circadian expression of stress related genes in lettuce possibly causing a repressed physiological status of the plant.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Accumulation In Plants ; Diurnal Rhythm ; Lactuca Sativa ; Stress Gene Expression ; Treated Wastewater

ISSN (print) / ISBN 0304-3894

e-ISSN 1873-3336

Journal Journal of Hazardous Materials

Quellenangaben Volume: 403, Article Number: 123881

Publisher Elsevier

Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Comparative Microbiome Analysis (COMI)
Institute of Network Biology (INET)

Grants Spanish Ministry of Science and Innovation
German Federal Ministry of Education and Research (BMBF) project DiControl
Federal Office for Agriculture and Food (Bundesamt fur Landwirtschaft und Ernahrung; BLE
Water Joint Programming Initiative (WATER-JPI) of the European Research Area (ERANET)