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Open Access Green as soon as Postprint is submitted to ZB.
Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: A case control pilot study.
Eur. Heart J. 29, 185-190 (2008)
Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes. METHODS AND RESULTS: Twenty patients with documented TdP under drugs with QT-prolonging potential were compared with 20 matched control individuals. An observer blinded to diagnosis manually measured lead-II, RR, and QT intervals from 30 consecutive beats. BVR was determined from Poincaré plots of QT intervals as short-term variability (STV(QT) = Sigma
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Torsades de Pointes; Drug induced Long QT Syndrome; Beat-to-beat Variability of repolarization; Proarrhythmia
ISSN (print) / ISBN
0195-668X
e-ISSN
1522-9645
Journal
European Heart Journal
Quellenangaben
Volume: 29,
Issue: 2,
Pages: 185-190
Publisher
Oxford University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Human Genetics (IHG)