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Frankó, A. ; Berti, L. ; Guirguis, A.* ; Hennenlotter, J.* ; Wagner, R. ; Scharpf, M.O.* ; Hrabě de Angelis, M. ; Wissmiller, K. ; Lickert, H. ; Stenzl, A.* ; Birkenfeld, A.L. ; Peter, A. ; Häring, H.-U. ; Lutz, S.Z.* ; Heni, M.

Characterization of hormone-dependent pathways in six human prostate-cancer cell lines: A gene-expression study.

Genes 11:1174 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Prostate cancer (PCa), the most incident cancer in men, is tightly regulated by endocrine signals. A number of different PCa cell lines are commonly used for in vitro experiments, but these are of diverse origin, and have very different cell-proliferation rates and hormone-response capacities. By analyzing the gene-expression pattern of main hormone pathways, we systematically compared six PCa cell lines and parental primary cells. We compared these cell lines (i) with each other and (ii) with PCa tissue samples from 11 patients. We found major differences in the gene-expression levels of androgen, insulin, estrogen, and oxysterol signaling between PCa tissue and cell lines, and between different cell lines. Our systematic characterization gives researchers a solid basis to choose the appropriate PCa cell model for the hormone pathway of interest.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Androgen Receptor ; Estrogen Receptor ; Gene Expression ; Insulin Receptor ; Prostate Cancer; Androgen Receptor; Inflammation; Hypoxia
ISSN (print) / ISBN 2073-4425
e-ISSN 2073-4425
Journal Genes
Quellenangaben Volume: 11, Issue: 10, Pages: , Article Number: 1174 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Experimental Genetics (IEG)
Institute of Diabetes and Regeneration Research (IDR)
Institute of Stem Cell Research (ISF)
Grants German Federal Ministry of Education and Research (BMBF)