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Determinants of health-related quality of life decline in interstitial lung disease.
Health Qual. Life Outcomes 18:334 (2020)
BackgroundHealth-related quality of life (HRQL) in interstitial lung disease (ILD) patients is impaired. We aimed to identify baseline predictors for HRQL decline within a 12-month observation period. MethodsWe analyzed 194 ILD patients from two German ILD-centers in the observational HILDA study. We employed the disease-specific King's Brief Interstitial Lung Disease questionnaire (K-BILD) with the subdomains 'psychological impact', 'chest symptoms' and 'breathlessness and activities', and the generic EQ-5D Visual Analog Scale (VAS). We evaluated how many patients experienced a clinically meaningful decline in HRQL. Subsequently, we investigated medical and sociodemographic factors as potential predictors of HRQL deterioration.ResultsWithin the study population (34.0% male, O age 61.7) mean HRQL scores hardly changed between baseline and follow up (K-BILD: 52.8 vs. 52.5 | VAS: 60.0 vs. 57.3). On the intra-individual level, 30.4% (n=59) experienced a clinically relevant deterioration in K-BILD total score and 35.4% (n=68) in VAS. Lower baseline forced vital capacity (FVC) % predicted determined HRQL decline in K-BILD total score (ss -coefficient: - 0.02, p=0.007), VAS (ss -coefficient: - 0.03, p<0.0001), and in the subdomain 'psychological impact' (-coefficient: - 0.02, p=0.014). Lower baseline diffusing capacity of carbon monoxide (DLCO) % predicted determined deterioration in 'breathlessness and activities' (ss -coefficient: - 0.04, p=0.003) and 'chest symptoms' (ss -coefficient: - 0.04, p=0.002). Additionally, increasing age predicted decline in 'psychological impact' (ss -coefficient: 0.06, p<0.007).ConclusionAround a third of ILD patients experienced a clinically relevant HRQL deterioration in a 12-month period, which was associated with baseline lung function values in all K-BILD domains. As lung function values are time-dependent variables with possible improvements, in contrast to age and ILD subtype, it, thus, seems important to improve lung function and prevent its decline in order to maintain HRQL on the possibly highest level.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diffuse Parenchymal Lung Disease ; Patient Reported Outcomes ; K-bild ; Eq-5d Vas ; Lung Function; Idiopathic Pulmonary-fibrosis; Functional Status; Pirfenidone; Questionnaire; Depression; Validation; Trial; Copd
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
1477-7525
e-ISSN
1477-7525
Quellenangaben
Volume: 18,
Issue: 1,
Article Number: 334
Publisher
BioMed Central
Publishing Place
Campus, 4 Crinan St, London N1 9xw, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Health Economics and Health Care Management (IGM)
Institute of Lung Health and Immunity (LHI)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
80000 - German Center for Lung Research
80000 - German Center for Lung Research
Research field(s)
Genetics and Epidemiology
Lung Research
Lung Research
PSP Element(s)
G-505300-001
G-501600-001
G-501800-533
G-505300-002
G-501600-001
G-501800-533
G-505300-002
Grants
Projekt DEAL
WOS ID
WOS:000578589300001
Scopus ID
85092571578
PubMed ID
33032602
Erfassungsdatum
2020-11-06