PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Kokot, H.* ; Kokot, B.* ; Sebastijanović, A.* ; Voss, C. ; Podlipec, R.* ; Zawilska, P.* ; Berthing, T.* ; Ballester-Lopez, C. ; Danielsen, P.H.* ; Contini, C.* ; Ivanov, M.* ; Krišelj, A.* ; Čotar, P.* ; Zhou, Q. ; Ponti, J.* ; Zhernovkov, V.* ; Schneemilch, M.* ; Doumandji, Z.* ; Pušnik, M.* ; Umek, P.* ; Pajk, S.* ; Joubert, O.* ; Schmid, O. ; Urbančič, I.* ; Irmler, M. ; Beckers, J. ; Lobaskin, V.* ; Halappanavar, S.* ; Quirke, N.* ; Lyubartsev, A.P.* ; Vogel, U.* ; Koklič, T.* ; Stöger, T. ; Štrancar, J.*

Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.

Adv. Mater. 32:e2003913 (2020)
Publ. Version/Full Text DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
27.398
3.997
5
8
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Advanced Microscopies ; Adverse Outcome Pathways ; Disease Prediction ; Material Safety And Health Hazards ; Mode Of Action; Molecular-dynamics; Chemical Safety; Nanomaterials; Responses; Nanotoxicology; Nanoparticles; Exposure; Matter; Hazard; Actin
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0935-9648
e-ISSN 1521-4095
Journal Advanced materials
Quellenangaben Volume: 32, Issue: , Pages: , Article Number: e2003913 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30202 - Environmental Health
30201 - Metabolic Health
Research field(s) Lung Research
Genetics and Epidemiology
PSP Element(s) G-505000-001
G-505000-007
G-505000-008
G-500600-004
Grants Crossing borders and scales - an interdisciplinary approach (CROSSING project)
Science Foundation Ireland
China Scholarship Council (CSC fellowship)
Genomics Research and Development Initiative and Chemicals Management Plan of Health Canada
Helmholtz Alliance "Aging and Metabolic Programming, AMPro"
Slovenian Research Agency Young Researcher Program
Slovenian Research Agency
EU Horizon 2020 Grant
DOI 10.1002/adma.202003913
WOS ID WOS:000579030900001
Scopus ID 85092622114
PubMed ID 33073368
Erfassungsdatum 2020-11-05
[➜Report correction]