Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
Lung regeneration: Implications of the diseased niche and ageing.
Eur. Respir. Rev. 29:200222 (2020)
Most chronic and acute lung diseases have no cure, leaving lung transplantation as the only option. Recent work has improved our understanding of the endogenous regenerative capacity of the lung and has helped identification of different progenitor cell populations, as well as exploration into inducing endogenous regeneration through pharmaceutical or biological therapies. Additionally, alternative approaches that aim at replacing lung progenitor cells and their progeny through cell therapy, or whole lung tissue through bioengineering approaches, have gained increasing attention. Although impressive progress has been made, efforts at regenerating functional lung tissue are still ineffective. Chronic and acute lung diseases are most prevalent in the elderly and alterations in progenitor cells with ageing, along with an increased inflammatory milieu, present major roadblocks for regeneration. Multiple cellular mechanisms, such as cellular senescence and mitochondrial dysfunction, are aberrantly regulated in the aged and diseased lung, which impairs regeneration. Existing as well as new human in vitro models are being developed, improved and adapted in order to study potential mechanisms of lung regeneration in different contexts. This review summarises recent advances in understanding endogenous as well as exogenous regeneration and the development of in vitro models for studying regenerative mechanisms.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Respiratory-distress-syndrome; Idiopathic Pulmonary-fibrosis; Epithelial-cell Senescence; Stem-cells; Basal-cells; Tgf-beta; Extracellular-matrix; Airway Epithelium; Adult Lung; Emphysema
ISSN (print) / ISBN
0905-9180
e-ISSN
1600-0617
Journal
European Respiratory Review
Quellenangaben
Volume: 29,
Issue: 157,
Article Number: 200222
Publisher
European Respiratory Society
Publishing Place
442 Glossop Rd, Sheffield S10 2px, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Lung Repair and Regeneration (LRR)
Grants
Knut och Alice Wallenbergs Stiftelse
Swedish Research Council
Bundesinstitut fur Risikobewertung (Grant "Lung aging in a dish")
Swedish Research Council
Bundesinstitut fur Risikobewertung (Grant "Lung aging in a dish")