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Kanellakis, N.I.* ; Asciak, R.* ; Hamid, M.A.* ; Yao, X.* ; McCole, M.* ; McGowan, S.* ; Seraia, E.* ; Hatch, S.* ; Hallifax, R.J.* ; Mercer, R.M.* ; Bedawi, E.O.* ; Jones, S.* ; Verrill, C.* ; Dobson, M.* ; George, V.* ; Stathopoulos, G.T. ; Peng, Y.* ; Ebner, D.* ; Dong, T.* ; Rahman, N.M.* ; Psallidas, I.*

Patient-derived malignant pleural mesothelioma cell cultures: A tool to advance biomarker-driven treatments.

Thorax 75, 1004-1008 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the biphasic MPM cells were capable of processing and presenting the neoantigen SSX-2 endogenously. In conclusion, patient-derived MPM cell cultures are a promising and faithful ex vivo model of MPM.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mesothelioma ; Pleural Disease; Establishment; Lines
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 75, Issue: 11, Pages: 1004-1008 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Lung Health and Immunity (LHI)
Grants Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS)
Oxfordshire Health Services Research Committee (OHSRC) Research Grant
Medical Research Council, UK
National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) grant
University of Oxford's Medical Sciences Division
NIHR Thames Valley and South Midlands Clinical Research Network
Oxford Cancer Centre (CRUK)
NIHR Oxford Biomedical Research Centre (Molecular Diagnostics theme)