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Kanellakis, N.I.* ; Asciak, R.* ; Hamid, M.A.* ; Yao, X.* ; McCole, M.* ; McGowan, S.* ; Seraia, E.* ; Hatch, S.* ; Hallifax, R.J.* ; Mercer, R.M.* ; Bedawi, E.O.* ; Jones, S.* ; Verrill, C.* ; Dobson, M.* ; George, V.* ; Stathopoulos, G.T. ; Peng, Y.* ; Ebner, D.* ; Dong, T.* ; Rahman, N.M.* ; Psallidas, I.*

Patient-derived malignant pleural mesothelioma cell cultures: A tool to advance biomarker-driven treatments.

Thorax 75, 1004-1008 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the biphasic MPM cells were capable of processing and presenting the neoantigen SSX-2 endogenously. In conclusion, patient-derived MPM cell cultures are a promising and faithful ex vivo model of MPM.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Mesothelioma ; Pleural Disease; Establishment; Lines
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 75, Issue: 11, Pages: 1004-1008 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-003
Grants Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS)
Oxfordshire Health Services Research Committee (OHSRC) Research Grant
Medical Research Council, UK
National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) grant
University of Oxford's Medical Sciences Division
NIHR Thames Valley and South Midlands Clinical Research Network
Oxford Cancer Centre (CRUK)
NIHR Oxford Biomedical Research Centre (Molecular Diagnostics theme)
DOI 10.1136/thoraxjnl-2020-215027
WOS ID WOS:000580440800013
Scopus ID 85093705620
PubMed ID 32943495
Erfassungsdatum 2020-11-13
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