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Emerging landscapes of tumor immunity and metabolism.
Front. Oncol. 10:575037 (2020)
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cancer ; Metabolism ; Immunity ; Reprogram ; Drug Resistance; T-cell Metabolism; Molecular Pathways; Antitumor Immunity; Glutamine Uptake; Cancer; Memory; Acid; Resistance; Kinase; Expression
ISSN (print) / ISBN
2234-943X
e-ISSN
2234-943X
Journal
Frontiers in Oncology
Quellenangaben
Volume: 10,
Article Number: 575037
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical Pathology (AAP)
Grants
Jiangsu Natural Science Foundation