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Lafci, B.* ; Mercep, E. ; Herraiz, J.L.* ; Deán-Ben, X.L.* ; Razansky, D.

Noninvasive multiparametric charac-terization of mammary tumors with transmission-reflection optoacoustic ultrasound.

Neoplasia 22, 770-777 (2020)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Development of imaging methods capable of furnishing tumor-specific morphological, functional, and molecular information is paramount for early diagnosis, staging, and treatment of breast cancer. Ultrasound (US) and optoacoustic (OA) imaging methods exhibit excellent traits for tumor imaging in terms of fast imaging speed, ease of use, excellent contrast, and lack of ionizing radiation. Here, we demonstrate simultaneous tomographic whole body imaging of optical absorption, US reflectivity, and speed of sound (SoS) in living mice. In vivo studies of 4T1 breast cancer xenografts models revealed synergistic and complementary value of the hybrid imaging approach for characterizing mammary tumors. While neovasculature surrounding the tumor areas were observed based on the vascular anatomy contrast provided by the OA data, the tumor boundaries could be discerned by segmenting hypoechoic structures in pulse-echo US images. Tumor delineation was further facilitated by enhancing the contrast and spatial resolution of the SoS maps with a full-wave inversion method. The malignant lesions could thus be distinguished from other hypoechoic regions based on the average SoS values. The reported findings corroborate the strong potential of the hybrid imaging approach for advancing cancer research in small animal models and fostering development of new clinical diagnostic approaches.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cancer Research ; Optoacoustic Imaging ; Photoacoustics ; Preclinical Imaging Of Tumors ; Speed Of Sound Imaging ; Ultrasound Computed Tomography; Tomography; Reconstruction; Attenuation; Speed
ISSN (print) / ISBN 1522-8002
e-ISSN 1476-5586
Journal Neoplasia : An International Journal for Oncology Research
Quellenangaben Volume: 22, Issue: 12, Pages: 770-777 Article Number: , Supplement: ,
Publisher Neoplasia Press
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants Spanish Ministry of Science and Innovation
Swiss Data Science Center
German Research Foundation