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Tapio, S. ; Little, M.P.* ; Kaiser, J.C. ; Impens, N.* ; Hamada, N.* ; Georgakilas, A.G.* ; Simar, D.* ; Salomaa, S.*

Ionizing radiation-induced circulatory and metabolic diseases.

Environ. Int. 146:106235 (2021)
Postprint Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Risks to health are the prime consideration in all human situations of ionizing radiation exposure and therefore of relevance to radiation protection in all occupational, medical, and public exposure situations. Over the past few decades, advances in therapeutic strategies have led to significant improvements in cancer survival rates. However, a wide range of long-term complications have been reported in cancer survivors, in particular circulatory diseases and their major risk factors, metabolic diseases. However, at lower levels of exposure, the evidence is less clear. Under real-life exposure scenarios, including radiotherapy, radiation effects in the whole organism will be determined mainly by the response of normal tissues receiving relatively low doses, and will be mediated and moderated by systemic effects. Therefore, there is an urgent need for further research on the impact of low-dose radiation. In this article, we review radiation-associated risks of circulatory and metabolic diseases in clinical, occupational or environmental exposure situations, addressing epidemiological, biological, risk modelling, and systems biology aspects, highlight the gaps in knowledge and discuss future directions to address these gaps.
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Publication type Article: Journal article
Document type Review
Keywords Circulatory Disease ; Endothelial ; Heart ; Ionizing Radiation ; Metabolic Syndrome ; Radiotherapy ; Systems Biology; Acute Lymphoblastic-leukemia; Ischemic-heart-disease; Intima-media Thickness; Long-term Survivors; Inflammatory Plaque Phenotype; Childhood-cancer Survivors; Genome-wide Association; Dose-escalation Trials; Atomic-bomb Survivors; Body-mass-index
Language english
Publication Year 2021
Prepublished in Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 146, Issue: , Pages: , Article Number: 106235 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
Institute of Radiation Medicine (IRM)
POF-Topic(s) 30202 - Environmental Health
30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
G-501391-001
Grants National Cancer Institute
National Institutes of Health
Division of Cancer Epidemiology and Genetics, National Cancer Institute
DOI 10.1016/j.envint.2020.106235
WOS ID WOS:000604619900005
Scopus ID 85094979767
PubMed ID 33157375
Erfassungsdatum 2020-12-09
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