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Hammer, G.P.* ; Seidenbusch, M.C.* ; Regulla, D.F. ; Spix, C.* ; Zeeb, H.* ; Schneider, K.* ; Blettner, M.*

Childhood cancer risk from conventional radiographic examinations for selected referral criteria: Results from a large cohort study.

Am. J. Roentgenol. 197, 217-223 (2011)
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OBJECTIVE: Little is known about the long-term effects of exposure to diagnostic ionizing radiation in childhood. Current estimates are made with models derived mainly from studies of atomic bomb survivors, a population that differs from today's patients in many respects. MATERIALS AND METHODS: We analyzed the cancer incidence among children who underwent diagnostic x-ray exposures between 1976 and 2003 in a large German university hospital. We reconstructed individual radiation doses for each examination and sorted results by groups of referral criteria for all cancers combined, solid tumors, and leukemia and lymphoma combined. RESULTS: A total of 68 incidence cancer cases between 1980 and 2006 were identified in a 78,527-patient cohort in the German childhood cancer registry: 28 leukemia, nine lymphoma, six tumors of the CNS, and 25 other tumors. The standardized incidence ratio for all cancers was 0.97 (95% CI, 0.75-1.23). Dose-response relations were analyzed by multivariable Poisson regression. Although the cancer incidence risk differed by initial referral criterion for radiographic examination, a positive dose-response relation was observed in five patients with endocrine or metabolic disease. CONCLUSION: Overall, we observed no increase in cancer risk among children and youths with very low radiation doses from diagnostic radiation, which is compatible with model calculations. The growing use of CT warrants further studies to assess associated cancer risk. Our work is an early contribution of epidemiologic data for quantifying these risks among young patients.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords cancer; child; cohort studies; incidence; ionizing radiation; risk
ISSN (print) / ISBN 0092-5381
e-ISSN 1546-3141
Journal American Journal of Roentgenology
Quellenangaben Volume: 197, Issue: 1, Pages: 217-223 Article Number: , Supplement: ,
Publisher American Roentgen Ray Society
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Medical Radiation Physics and Diagnostics (AMSD)