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Guha, N.* ; Bouaoun, L.* ; Kromhout, H.* ; Vermeulen, R.* ; Brüning, T.* ; Behrens, T.* ; Peters, S.* ; Luzon, V.* ; Siemiatycki, J.* ; Xu, M.* ; Kendzia, B.* ; Guénel, P.* ; Luce, D.* ; Karrasch, S. ; Wichmann, H.-E. ; Consonni, D.* ; Landi, M.T.* ; Caporaso, N.E.* ; Gustavsson, P.* ; Plato, N.* ; Merletti, F.* ; Mirabelli, D.* ; Richiardi, L.* ; Jöckel, K.H.* ; Ahrens, W.* ; Pohlabeln, H.* ; Tse, L.A.* ; Yu, I.T.S.* ; Tardón, A.* ; Boffetta, P.* ; Zaridze, D.* ; Tmannetje, A.* ; Pearce, N.* ; Davies, M.P.A.* ; Lissowska, J.* ; Świątkowska, B.* ; McLaughlin, J.* ; Demers, P.A.* ; Bencko, V.* ; Foretova, L.* ; Janout, V.* ; Pándics, T.* ; Fabianova, E.* ; Mates, D.* ; Forastiere, F.* ; Bueno-de-Mesquita, B.* ; Schüz, J.* ; Straif, K.* ; Olsson, A.*

Lung cancer risk in painters: Results from the SYNERGY pooled case-control study consortium.

Occup. Environ. Med. 78, 269-278 (2021)
Publ. Version/Full Text DOI PMC
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Creative Commons Lizenzvertrag
Objectives: We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods: Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results: Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions: Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cancer ; Epidemiology ; Painters ; Smoking
Language english
Publication Year 2021
Prepublished in Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 1351-0711
e-ISSN 1470-7926
Journal Occupational and Environmental Medicine
Quellenangaben Volume: 78, Issue: 4, Pages: 269-278 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-009
G-501800-401
Grants German Social Accident Insurance (DGUV)
DOI 10.1136/oemed-2020-106770
WOS ID WOS:000629177900007
Scopus ID 85096056724
PubMed ID 33115922
Erfassungsdatum 2020-12-10
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