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Litviňuková, M.* ; Talavera-López, C.* ; Maatz, H.* ; Reichart, D.* ; Worth, C.L.* ; Lindberg, E.L.* ; Kanda, M.* ; Polanski, K.* ; Heinig, M. ; Lee, M.* ; Nadelmann, E.R.* ; Roberts, K.* ; Tuck, L.* ; Fasouli, E.S.* ; DeLaughter, D.M.* ; McDonough, B.* ; Wakimoto, H.* ; Gorham, J.M.* ; Samari, S.* ; Mahbubani, K.T.* ; Saeb-Parsy, K.* ; Patone, G.* ; Boyle, J.J.* ; Zhang, H.* ; Viveiros, A.* ; Oudit, G.Y.* ; Bayraktar, O.A.* ; Seidman, J.G.* ; Seidman, C.E.* ; Noseda, M.* ; Hubner, N.* ; Teichmann, S.A.*

Cells of the adult human heart.

Nature 588, 466-472 (2020)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Resident Cardiac Macrophages; Smooth-muscle; Rna-seq; Endothelial-cells; Myocardial Injury; Adipose-tissue; Growth-factor; Expression; Protein; Gene
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 588, Issue: 7838, Pages: 466-472 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Grants NHLBI NIH HHS
Wellcome Trust