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Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming.
Neurobiol. Dis. 148:105174 (2021)
The vulnerability of the mammalian brain is mainly due to its limited ability to generate new neurons once fully matured. Direct conversion of non-neuronal cells to neurons opens up a new avenue for therapeutic intervention and has made great strides also for in vivo applications in the injured brain. These great achievements raise the issue of adequate identity and chromatin hallmarks of the induced neurons. This may be particularly important, as aberrant epigenetic settings may reveal their adverse effects only in certain brain activity states. Therefore, we review here the knowledge about epigenetic memory and partially resetting of chromatin hallmarks from other reprogramming fields, before moving to the knowledge in direct neuronal reprogramming, which is still limited. Most importantly, novel tools are available now to manipulate specific epigenetic marks at specific sites of the genome. Applying these will eventually allow erasing aberrant epigenetic memory and paving the way towards new therapeutic approaches for brain repair.
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Publication type
Article: Journal article
Document type
Review
Keywords
Direct Reprogramming ; Epigenetics ; Neural Lineage; Pluripotent Stem-cells; Dna Methylation; Somatic-cells; Human Neurons; Brain Repair; Glial-cells; Muller Glia; Memory; Heterochromatin; Expression
ISSN (print) / ISBN
0969-9961
e-ISSN
1095-953X
Journal
Neurobiology of Disease
Quellenangaben
Volume: 148,
Article Number: 105174
Publisher
Elsevier
Publishing Place
525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
Grants
German Research Foundation
ERC
ERC