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Liu, S.* ; Jørgensen, J.T.* ; Ljungman, P.* ; Pershagen, G.* ; Bellander, T.* ; Leander, K.* ; Magnusson, P.K.E.* ; Rizzuto, D.* ; Hvidtfeldt, U.A.* ; Raaschou-Nielsen, O.* ; Wolf, K. ; Hoffmann, B.* ; Brunekreef, B.* ; Strak, M.* ; Chen, J.* ; Mehta, A.* ; Atkinson, R.W.* ; Bauwelinck, M.* ; Varraso, R.* ; Boutron-Ruault, M.C.* ; Brandt, J.* ; Cesaroni, G.* ; Forastiere, F.* ; Fecht, D.* ; Gulliver, J.* ; Hertel, O.* ; de Hoogh, K.* ; Janssen, N.A.H.* ; Katsouyanni, K.* ; Ketzel, M.* ; Klompmaker, J.O.* ; Nagel, G.* ; Oftedal, B.* ; Peters, A. ; Tjønneland, A.* ; Rodopoulou, S.P.* ; Samoli, E.* ; Kristoffersen, D.T.* ; Sigsgaard, T.* ; Stafoggia, M.* ; Vienneau, D.* ; Weinmayr, G.* ; Hoek, G.* ; Andersen, Z.J.*

Long-term exposure to low-level air pollution and incidence of asthma: The ELAPSE project.

Environ. Int. 146:106267 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, while evidence is still insufficient. Within the multicentre project "Effects of Low-Level Air Pollution: A Study in Europe" (ELAPSE), we examined the associations of long-term exposures to particulate matter with diameter<2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) with asthma incidence in adults. METHODS: We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders. RESULTS: Of 98 326 participants, 1965 developed asthma during a 16.6 years mean follow-up. We observed associations in fully adjusted models with hazard ratios and 95% confidence intervals of 1.22 (1.04-1.43) per 5 μg·m-3 for PM2.5, 1.17 (1.10-1.25) per 10 µg·m-3 for NO2, and 1.15 (1.08-1.23) per 0.5 10-5 m-1 for BC. Hazard ratios were larger in cohort subsets with exposure levels below the EU and US limit values and possibly WHO guidelines for PM2.5 and NO2. NO2 and BC estimates remained unchanged in two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated to unity. The concentration response curves showed no evidence of a threshold. CONCLUSIONS: Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Air Pollution ; Copd Incidence ; Low-level Exposure; Lung-function Decline; Fine Particulate Matter; Prospective Cohort; Global Burden; Risk-factors; Copd; Hospitalization; Associations; Prevalence; Models
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 146, Issue: , Pages: , Article Number: 106267 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants Swedish Research Council
China Scholarship Council
Health Effects Institute Research Agreement