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Open Access Green as soon as Postprint is submitted to ZB.
Kidney-derived PCSK9-a new driver of hyperlipidemia in nephrotic syndrome?
Kidney Int. 98, 1393-1395 (2020)
Increased plasma concentrations of proprotein convertase subtilisin/kexin type 9 or PCSK9, which reduces hepatic uptake of low-density lipoprotein by downregulation of the low-density lipoprotein receptor, have been reported in nephrotic patients and might contribute to hyperlipidemia in nephrotic syndrome. The results of the study by Molina-Jijon et al. found that renal PCSK9 expression was upregulated in the collecting duct of nephrotic patients and animals, suggesting that the kidney might be a major source for plasma PCSK9 in nephrotic syndrome.
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Publication type
Article: Journal article
Document type
Other: Opinion
Keywords
Subtilisin/kexin Type 9; Metabolism
ISSN (print) / ISBN
0085-2538
e-ISSN
1523-1755
Journal
Kidney International
Quellenangaben
Volume: 98,
Issue: 6,
Pages: 1393-1395
Publisher
Nature Publishing Group
Publishing Place
Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed