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Fueessl, L.U. ; Rottenkolber, M. ; Gar, C. ; Potzel, A. ; Keilen, J. ; Seissler, J. ; Lechner, A.

No deleterious effect of an additional pregnancy on glucose metabolism in women with previous gestational diabetes mellitus.

Diabetes Res. Clin. Pract. 171:108543 (2021)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Objective: Women with gestational diabetes mellitus (GDM) often develop type 2 diabetes later in life. It remains unclear whether this results solely from a common underlying predisposition or, whether a pregnancy itself persistently impairs glucose metabolism in predisposed women. We therefore examined how an additional pregnancy affected different aspects of glucose metabolism in women with previous GDM. Research design and methods: Nested case-control study within the prospective cohort study PPSDiab, recruited in Munich, Germany from 2011-16. Cases (n = 41): women with previous GDM who completed an additional pregnancy; controls: no additional pregnancy, pairwise matching. Endpoints: change of the area under the glucose curve (AUGC) of an oral glucose tolerance, of plasma glucose at 60′ of the test (PG 60′), of the insulin sensitivity index (ISI) and of the disposition index (DI), all between before and after the additional pregnancy in cases/the corresponding observation period in controls. Results: We observed no significant difference between cases and controls in the primary [ratio AUGC 1.05(0.92–1.15) vs. 0.97(0.85–1.14); p = 0.21] and in the secondary endpoints [difference PG 60′, ratio ISI and ratio DI. Conclusion: We did not find a deleterious effect of an additional pregnancy on glucose metabolism in women with previous GDM.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gestational Diabetes ; Type 2 Diabetes Mellitus
ISSN (print) / ISBN 0168-8227
e-ISSN 1872-8227
Journal Diabetes Research and Clinical Practice
Quellenangaben Volume: 171, Issue: , Pages: , Article Number: 108543 Supplement: ,
Publisher Elsevier
Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Biomarker for the subclassification of T2DM (KKG-KDB)
Grants German Center for Diabetes Research
Klinikum der Universitat Munchen
Helmholtz Zentrum Munchen