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Stylogiannis, A. ; Riobo, L. ; Prade, L. ; Glasl, S. ; Klein, S.* ; Lucidi, G.* ; Fuchs, M.* ; Saur, D.* ; Ntziachristos, V.

Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation.

Opt. Lett. 45, 6579-6582 (2020)

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	Open Access Gold (Paid Option)

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Optical sensors developed for the assessment of oxygen in tissue microvasculature, such as those based on near-infrared spectroscopy, are limited in application by light scattering. Optoacoustic methods are insensitive to light scattering, and therefore, they can provide higher specificity and accuracy when quantifying local vascular oxygenation. However, currently, to the best of our knowledge, there is no low-cost, single point, optoacoustic sensor for the dedicated measurement of oxygen saturation in tissue microvasculature. This work introduces a spectroscopic optoacoustic sensor (SPOAS) for the non-invasive measurement of local vascular oxygenation in real time. SPOAS employs continuous wave laser diodes and measures at a single point, which makes it low-cost and portable. The SPOAS performance was benchmarked using blood phantoms, and it showed excellent linear correlation (R2 = 0.98) with a blood gas analyzer. Subsequent measurements of local vascular oxygenation in living mice during an oxygen stress test correlated well with simultaneous readings from a reference instrument.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Blood Oxygenation; Tomography; Principles; Saturation

ISSN (print) / ISBN 0146-9592

e-ISSN 1539-4794

Journal Optics Letters

Quellenangaben Volume: 45, Issue: 24, Pages: 6579-6582

Publisher Optical Society of America (OSA)

Publishing Place 2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)

Grants Bundesministerium für Bildung und Forschung
H2020 European Union
H2020 European Research Council