PuSH - Publication Server of Helmholtz Zentrum München: Mendelian randomization study on amino acid metabolism suggests tyrosine as causal trait for type 2 diabetes.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Jäger, S.* ; Cuadrat, R.* ; Wittenbecher, C.* ; Floegel, A.* ; Hoffmann, P.* ; Prehn, C. ; Adamski, J. ; Pischon, T.* ; Schulze, M.B.*

Mendelian randomization study on amino acid metabolism suggests tyrosine as causal trait for type 2 diabetes.

Nutrients 12:3890 (2020)

Postprint

Research data

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Circulating levels of branched-chain amino acids, glycine, or aromatic amino acids have been associated with risk of type 2 diabetes. However, whether those associations reflect causal relationships or are rather driven by early processes of disease development is unclear. We selected diabetes-related amino acid ratios based on metabolic network structures and investigated causal effects of these ratios and single amino acids on the risk of type 2 diabetes in two-sample Mendelian randomization studies. Selection of genetic instruments for amino acid traits relied on genome-wide association studies in a representative sub-cohort (up to 2265 participants) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study and public data from genome-wide association studies on single amino acids. For the selected instruments, outcome associations were drawn from the DIAGRAM (DIAbetes Genetics Replication And Meta-analysis, 74,124 cases and 824,006 controls) consortium. Mendelian randomization results indicate an inverse association for a per standard deviation increase in ln-transformed tyrosine/methionine ratio with type 2 diabetes (OR = 0.87 (0.81–0.93)). Multivariable Mendelian randomization revealed inverse association for higher log10-transformed tyrosine levels with type 2 diabetes (OR = 0.19 (0.04–0.88)), independent of other amino acids. Tyrosine might be a causal trait for type 2 diabetes independent of other diabetes-associated amino acids.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Amino Acids ; Gwas ; Mendelian Randomization ; Type 2 Diabetes ; Tyrosine; Genome-wide Association; Genetic-variants; Insulin-resistance; Risk; Metaanalysis; Imputation; Loci

ISSN (print) / ISBN 2072-6643

e-ISSN 2072-6643

Journal Nutrients

Quellenangaben Volume: 12, Issue: 12, Article Number: 3890

Publisher MDPI

Publishing Place Basel

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)

Grants State of Brandenburg (DZD)
German Ministry of Education and Research (BMBF)
German Cancer Aid
Federal Ministry of Science, Germany
German Ministry of Education and Research (BMBF) and the State of Brandenburg
European Community
European Union