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von Schirnding, C.* ; Giopanou, I.* ; Hermawan, A.* ; Wehl, L.* ; Ntaliarda, G.* ; Illes, R.* ; Datz, S.* ; Geisslinger, F.* ; Bartel, K.* ; Sommer, A.-K.* ; Lianou, M.* ; Weiß, V.* ; Feckl, J.* ; Vollmar, A.M.* ; Bräuchle, C.* ; Stathopoulos, G.T. ; Wagner, E.* ; Roidl, A.* ; Bein, T.* ; Engelke, H.*

Synergistic combination of calcium and citrate in mesoporous nanoparticles targets pleural tumors.

Chem 7, 480-494 (2021)

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Conventional chemotherapy leads to severe adverse effects since it involves systemic administration of toxic drugs at high dosage. Unlike traditional chemotherapeutics, calcium phosphate and citrate have both been discussed as very promising anticancer agents and are not inherently toxic. Yet, their breakthrough has been hampered by the lack of an administration approach that overcomes the strict regulatory mechanisms of the cell. Here, we present a combinatorial administration of calcium, phosphate, and citrate as colloidal, amorphous nanoparticles (CPCs) that selectively kill cancer cells without involvement of inherently toxic drugs. The particles are toxic neither before endosomal release nor after their degradation. This highly selective toxicity allowed us to successfully treat two different aggressive pleural tumors in mice, reducing their size by about 40% and 70% after only two local applications. Safety assessment studies over 2 months show no signs of adverse effects except for slightly enhanced pleural thickening after eight applications.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Anticancer Agent ; Calcium Phosphate ; Citrate ; Ion Release ; Mesoporous Nanoparticles ; Pleural Tumor ; Sdg3: Good Health And Well-being ; Selective Toxicity; Drug-delivery; Phosphate; Release; Sirna; Nano

ISSN (print) / ISBN 2451-9294

e-ISSN 2451-9294

Journal Chem

Quellenangaben Volume: 7, Issue: 2, Pages: 480-494

Publisher Cell Press

Publishing Place Cambridge

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Lung Health and Immunity (LHI)

Grants Center for NanoScience Munich (CeNS), Ludwig-Maximilians-University (LMU excellent funds)
DFG
Islamic Development Bank
Hanns-Seidel-Stiftung
European Research Council
Excellence Cluster Nanosystems Initiative Munich (NIM)