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Hulstaert, E.* ; Morlion, A.* ; Avila Cobos, F.* ; Verniers, K.* ; Nuytens, J.* ; Vanden Eynde, E.* ; Yigit, N.* ; Anckaert, J.* ; Geerts, A.* ; Hindryckx, P.* ; Jacques, P.* ; Brusselle, G.* ; Bracke, K.R.* ; Maes, T.* ; Malfait, T.* ; Derveaux, T.* ; Ninclaus, V.* ; Van Cauwenbergh, C.* ; Roelens, K.* ; Roets, E.* ; Hemelsoet, D.* ; Tilleman, K.* ; Brochez, L.* ; Kuersten, S.* ; Simon, L.M.* ; Karg, S. ; Kautzky-Willers, A.* ; Leutner, M.* ; Nöhammer, C.* ; Slaby, O.* ; Prins, R.W.* ; Koster, J.* ; Lefever, S.* ; Schroth, G.P.* ; Vandesompele, J.* ; Mestdagh, P.*

Charting extracellular transcriptomes in the Human Biofluid RNA Atlas.

Cell Rep. 33:108552 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids. By means of synthetic spike-in controls, we compare RNA content across biofluids, revealing a 10,000-fold difference in concentration. The circular RNA fraction is increased in most biofluids compared to tissues. Each biofluid transcriptome is enriched for RNA molecules derived from specific tissues and cell types. Our atlas enables an informed selection of the most relevant biofluid to monitor particular diseases. To verify the biomarker potential in these biofluids, four validation cohorts representing a broad spectrum of diseases were profiled, revealing numerous differential RNAs between case and control subjects. Spike-normalized data are publicly available in the R2 web portal for further exploration.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biofluids ; Biomarker ; Cell-free Rna ; Circular Rna ; Extracellular Rna ; Liquid Biopsy ; Messenger Rna ; Rna Sequencing ; Small Rna; Messenger-rna; Circular Rna; Expression; Landscape; Microrna; Biomarkers
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 33, Issue: 13, Pages: , Article Number: 108552 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-553800-001
Grants NCI (Exploring Cancer Medicine for Sarcoma and Rare Cancers)
Special Research Fund (BOF) scholarships of Ghent University
Ghent University
"Kom Op Tegen Kanker"(Stand Up To Cancer, the Flemish cancer society)
Czech Ministry of Health
NHGRI
Fund for Scientific Research Flanders (FWO)
DOI 10.1016/j.celrep.2020.108552
WOS ID WOS:000604449500006
Scopus ID 85098622623
PubMed ID 33378673
Erfassungsdatum 2021-02-09
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