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Hermant, C. ; Torres-Padilla, M.E.

TFs for TEs: The transcription factor repertoire of mammalian transposable elements.

Genes Dev. 35, 22-39 (2021)
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Transposable elements (TEs) are genetic elements capable of changing position within the genome. Although their mobilization can constitute a threat to genome integrity, nearly half of modern mammalian genomes are composed of remnants of TE insertions. The first critical step for a successful transposition cycle is the generation of a full-length transcript. TEs have evolved cis-regulatory elements enabling them to recruit host-encoded factors driving their own, selfish transcription. TEs are generally transcriptionally silenced in somatic cells, and the mechanisms underlying their repression have been extensively studied. However, during germline formation, preimplantation development, and tumorigenesis, specific TE families are highly expressed. Understanding the molecular players at stake in these contexts is of utmost importance to establish the mechanisms regulating TEs, as well as the importance of their transcription to the biology of the host. Here, we review the transcription factors known to be involved in the sequence-specific recognition and transcriptional activation of specific TE families or subfamilies. We discuss the diversity of TE regulatory elements within mammalian genomes and highlight the importance of TE mobilization in the dispersal of transcription factor-binding sites over the course of evolution.
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Publication type Article: Journal article
Document type Review
Keywords Co-option ; Regulatory Elements ; Retrotransposons ; Transcriptional Regulation; Long Terminal Repeats; Immunodeficiency-virus Type-1; Human Endogenous Retroviruses; Human L1 Transcription; Dna Methylation; Regulatory Sequences; Antisense Promoter; Gene-expression; Mouse Dux; Line-1
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0890-9369
e-ISSN 1549-5477
Journal Genes and Development
Quellenangaben Volume: 35, Issue: 1-2, Pages: 22-39 Article Number: , Supplement: ,
Publisher Cold Spring Harbor Laboratory Press
Publishing Place 1 Bungtown Rd, Cold Spring Harbor, Ny 11724 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Epigenetics and Stem Cells (IES)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-506200-001
Grants H2020 Marie Sklodowska-Curie Actions (ITN EpiSystem and ChromDesign)
Deutsche Forschungsgemeinschaft
Helmholtz-Gemeinschaft
DOI 10.1101/gad.344473.120
WOS ID WOS:000607145700002
Scopus ID 85099331946
PubMed ID 33397727
Erfassungsdatum 2021-01-12
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