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Qi, L.* ; Cornelis, M.C.* ; Kraft, P.* ; Stanya, K.J.* ; Kao, W.H.L.* ; Pankow, J.S.* ; Dupuis, J.* ; Florez, J.C* ; Fox, C.S.* ; Paré, G.* ; Sun, Q.* ; Girman, C.J.* ; Laurie, C.C.* ; Mirel, D.B.* ; Manolio, T.A.* ; Chasman, D.I.* ; Boerwinkle, E.* ; Ridker, P.M.* ; Hunter, D.J.* ; Meigs, J.B.* ; Lee, C.H.* ; van Dam, R.M.* ; Hu, F.B.*

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.

Hum. Mol. Genet. 19, 2706-2715 (2010)
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To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8)). The frequency of the risk-lowering allele T is 0.23. Variants in this region were nominally related to lower fasting glucose and HOMA-IR in the MAGIC consortium (P<0.05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords GENOME-WIDE ASSOCIATION; PHYSICAL-ACTIVITY; LIFE-STYLE; RISK; MELLITUS; LOCI; WOMEN; MEN; CLASSIFICATION; METAANALYSIS
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Journal Human Molecular Genetics
Quellenangaben Volume: 19, Issue: 13, Pages: 2706-2715 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)