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Open Access Green as soon as Postprint is submitted to ZB.
Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer.
Mol. Cell. Endocrinol. 248, 114-117 (2006)
Estrogen-dependent endometrial cancer is related to unopposed and prolonged estrogen stimulation. We examined the expression of estrogen-metabolizing enzymes in correlation with the ERα and ERβ estrogen receptors in human endometrial Ishikawa adenocarcinoma cells and in endometrial cancer specimens and adjacent normal endometrium from the same patients. Real-time PCR analysis revealed that both estrogen receptors and selected estrogen-metabolizing enzymes were expressed in the Ishikawa cells and in endometrial tissue. We detected higher expression of ERα than ERβ, higher expression of sulfatase than sulfotransferase and low expression of aromatase in the Ishikawa cells and the tissue, as well as higher levels of type 2 17β-hydroxysteroid dehydrogenase (17β-HSD) in normal and diseased tissue than in the Ishikawa cells. When we compared the expression in endometrial cancer samples and in the adjacent normal endometrium, ERα and ERβ, sulfatase and sulfotransferase were seen to be downregulated in the majority of the cancerous tissue specimens.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
17β-Hydroxysteroid dehydrogenase; Aromatase; Sulfatase; Sulfotransferase; Estrogen receptors
ISSN (print) / ISBN
0303-7207
e-ISSN
1872-8057
Quellenangaben
Volume: 248,
Issue: 1-2,
Pages: 114-117
Publisher
Elsevier
Publishing Place
Shannon
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)