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Brandes, R.P.* ; Dueck, A.* ; Engelhardt, S.* ; Kaulich, M.* ; Kupatt, C.* ; De Angelis, M.T.* ; Leisegang, M.S.* ; le Noble, F.* ; Moretti, A.* ; Müller, O.J.* ; Skryabin, B.V.* ; Thum, T.* ; Wurst, W.

DGK and DZHK position paper on genome editing: Basic science applications and future perspective.

Basic Res. Cardiol. 116:2 (2021)

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	Open Access Gold (Paid Option)

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For a long time, gene editing had been a scientific concept, which was limited to a few applications. With recent developments, following the discovery of TALEN zinc-finger endonucleases and in particular the CRISPR/Cas system, gene editing has become a technique applicable in most laboratories. The current gain- and loss-of function models in basic science are revolutionary as they allow unbiased screens of unprecedented depth and complexity and rapid development of transgenic animals. Modifications of CRISPR/Cas have been developed to precisely interrogate epigenetic regulation or to visualize DNA complexes. Moreover, gene editing as a clinical treatment option is rapidly developing with first trials on the way. This article reviews the most recent progress in the field, covering expert opinions gathered during joint conferences on genome editing of the German Cardiac Society (DGK) and the German Center for Cardiovascular Research (DZHK). Particularly focusing on the translational aspect and the combination of cellular and animal applications, the authors aim to provide direction for the development of the field and the most frequent applications with their problems.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Animal Models ; Animal Models ; Crispr/cas ; Genome Editing

ISSN (print) / ISBN 0300-8428

e-ISSN 1435-1803

Journal Basic Research in Cardiology

Quellenangaben Volume: 116, Issue: 1, Article Number: 2

Publisher Springer

Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Developmental Genetics (IDG)

Grants DZHK
DGK
Projekt DEAL