PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Rackles, E.* ; Witting,M. ; Forné, I.* ; Zhang, X.* ; Zacherl, J.* ; Schrott, S.* ; Fischer, C.* ; Ewbank, J.J.* ; Osman, C.* ; Imhof, A.* ; Rolland, S.G.*

Reduced peroxisomal import triggers peroxisomal retrograde signaling.

Cell Rep. 34:108653 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that peroxisomal import stress caused by knockdown of the peroxisomal matrix import receptor prx-5/PEX5 triggers NHR-49/peroxisome proliferator activated receptor alpha (PPARα)- and MDT-15/MED15-dependent upregulation of the peroxisomal Lon protease lonp-2/LONP2 and the peroxisomal catalase ctl-2/CAT. Using proteomic and transcriptomic analyses, we show that proteins involved in peroxisomal lipid metabolism and immunity are also upregulated upon prx-5(RNAi). While the PRS can be triggered by perturbation of peroxisomal β-oxidation, we also observed hallmarks of PRS activation upon infection with Pseudomonas aeruginosa. We propose that the PRS, in addition to a role in lipid metabolism homeostasis, may act as a surveillance mechanism to protect against pathogens.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
9.423
1.943
2
3
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords C. Elegans Immunity ; C. elegans ; Mdt-15 ; Nhr-49 ; Peroxisomal Lon Protease ; Peroxisomal Catalase ; Peroxisomal Retrograde Signaling ; Peroxisomal β-oxidation; Caenorhabditis-elegans; Gene-expression; C-elegans; Protein Import; Beta-oxidation; Responses; Biogenesis; Disorders; Infection; Bacterial
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 34, Issue: 3, Pages: , Article Number: 108653 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
PSP Element(s) G-504800-001
Grants European Research Council
Deutsche Forschungsgemeinschaft
Institute for Basic Science
Inserm
CNRS
AMU
Agence Nationale de la Recherche
ChineseScholarship Council
National Institutes of Health National Center for Research Resources
DOI 10.1016/j.celrep.2020.108653
WOS ID WOS:000609627300019
Scopus ID 85099538153
PubMed ID 33472070
Erfassungsdatum 2021-03-29
[➜Report correction]